Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) is often diagnosed at an advanced stage, thus understanding the molecular basis for EAC invasion and metastasis is critical. Here we report that SPP1/OPN was highly overexpressed in primary EACs and intracellularly localized to tumor cells. We further demonstrate that...

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Udgivet i:Oncotarget
Main Authors: Lin, Jules, Myers, Amy L., Wang, Zhuwen, Nancarrow, Derek J., Ferrer-Torres, Daysha, Handlogten, Amy, Leverenz, Kimmy, Bao, Julia, Thomas, Dafydd G., Wang, Thomas D., Orringer, Mark B., Reddy, Rishindra M., Chang, Andrew C., Beer, David G., Lin, Lin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673160/
https://ncbi.nlm.nih.gov/pubmed/26068949
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