Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression

Improved efficacy of neoadjuvant endocrine-targeting therapies in luminal breast carcinomas could be achieved with optimal use of pathway targeting agents. In a mouse model of ductal breast carcinoma we identify a tumor regressive stromal reaction that is induced by neoadjuvant endocrine therapy. Th...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Polo, María Laura, Riggio, Marina, May, María, Rodríguez, María Jimena, Perrone, María Cecilia, Stallings-Mann, Melody, Kaen, Diego, Frost, Marlene, Goetz, Matthew, Boughey, Judy, Lanari, Claudia, Radisky, Derek, Novaro, Virginia
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673148/
https://ncbi.nlm.nih.gov/pubmed/26098779
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