Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

Tumor cell metabolic heterogeneity is thought to contribute to tumor recurrence, distant metastasis and chemo-resistance in cancer patients, driving poor clinical outcome. To better understand tumor metabolic heterogeneity, here we used the MCF7 breast cancer line as a model system to metabolically...

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Publicado en:Oncotarget
Autores principales: Lamb, Rebecca, Ozsvari, Bela, Bonuccelli, Gloria, Smith, Duncan L., Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Clarke, Robert B., Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673134/
https://ncbi.nlm.nih.gov/pubmed/26323205
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