Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain

17-β estradiol (E2) has been implicated as neuroprotective in a variety of neurodegenerative disorders. However, the underlying mechanism remains unknown. Here, we provide genetic evidence, using forebrain-specific knockout (FBKO) mice, that proline-, glutamic acid-, and leucine-rich protein 1 (PELP...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sareddy, Gangadhara R., Zhang, Quanguang, Wang, Ruimin, Scott, Erin, Zou, Yi, O'Connor, Jason C., Chen, Yidong, Dong, Yan, Vadlamudi, Ratna K., Brann, Darrell
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672783/
https://ncbi.nlm.nih.gov/pubmed/26627258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516729112
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