Gene Delivery by Subconjunctival Injection of Adenovirus in Rats: A Study of Local Distribution, Transgene Duration and Safety

Subconjunctival injection is a minimally invasive route for gene delivery to ocular tissues, but has traditionally been limited to use in the cornea. The accurate ocular distribution of virus has not, however, been previously investigated. Adenovirus is an attractive gene vector as it can deliver la...

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Publicado en:PLoS One
Main Authors: Liu, Guei-Sheung, Wang, Jiang-Hui, Lee, Jia Hui, Tsai, Pei-Jhen, Tsai, Han-En, Sheu, Shwu-Jiuan, Lin, Hsiu-Chen, Dusting, Gregory J., Tai, Ming-Hong, Bee, Youn-Shen
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671571/
https://ncbi.nlm.nih.gov/pubmed/26642208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143956
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