The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P

Since the α1-adrenergic antagonist prazosin (PRZ) was introduced into medicine as a treatment for hypertension and benign prostate hyperplasia, several studies have shown that PRZ induces apoptosis in various cell types and interferes with endocytotic trafficking. Because PRZ is also able to induce...

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Veröffentlicht in:Toxicology
Hauptverfasser: Fuchs, Robert, Stracke, Anika, Ebner, Nadine, Zeller, Christian Wolfgang, Raninger, Anna Maria, Schittmayer, Matthias, Kueznik, Tatjana, Absenger-Novak, Markus, Birner-Gruenberger, Ruth
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671317/
https://ncbi.nlm.nih.gov/pubmed/26449523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2015.09.008
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