Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages

Sphingomyelinases secreted by pathogenic bacteria play important roles in host-pathogen interactions ranging from interfering with phagocytosis and oxidative burst to iron acquisition. This study shows that the Mtb protein Rv0888 possesses potent sphingomyelinase activity cleaving sphingomyelin, a m...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Microbiol
Hauptverfasser: Speer, Alexander, Sun, Jim, Danilchanka, Olga, Meikle, Virginia, Rowland, Jennifer L., Walter, Kerstin, Buck, Bradford R., Pavlenok, Mikhail, Hölscher, Christoph, Ehrt, Sabine, Niederweis, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671274/
https://ncbi.nlm.nih.gov/pubmed/26036301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13073
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