MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells

MicroRNA-122 (miR-122) is one of the most abundant miRs in the liver. Previous studies have demonstrated that miR-122 plays a role in inflammation in the liver and functions in hepatic stellate cells (HSCs), which reside in the space of Disse. Here, we showed that the transient inhibition of PKR-act...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Nakamura, Masato, Kanda, Tatsuo, Sasaki, Reina, Haga, Yuki, Jiang, Xia, Wu, Shuang, Nakamoto, Shingo, Yokosuka, Osamu
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670168/
https://ncbi.nlm.nih.gov/pubmed/26636761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144295
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