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Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria.

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder arising in a multipotent hemopoietic stem cell. PNH manifests clinically with intravascular hemolysis resulting from an increased sensitivity of the red cells belonging to the PNH clone to complement-mediated lysis. Numerous studies have...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hillmen, P, Bessler, M, Mason, P J, Watkins, W M, Luzzatto, L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46698/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8389477/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5272
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