XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death

Here we study links between aminoglycoside-induced mistranslation, protein misfolding and neuropathy. We demonstrate that aminoglycosides induce misreading in mammalian cells and assess endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways. Genome-wide transcriptome and prot...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Oishi, N, Duscha, S, Boukari, H, Meyer, M, Xie, J, Wei, G, Schrepfer, T, Roschitzki, B, Boettger, E C, Schacht, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669688/
https://ncbi.nlm.nih.gov/pubmed/25973683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.108
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