Tet1 Oxidase Regulates Neuronal Gene Transcription, Active DNA Hydroxy-methylation, Object Location Memory, and Threat Recognition Memory

A dynamic equilibrium between DNA methylation and demethylation of neuronal activity-regulated genes is crucial for memory processes. However, the mechanisms underlying this equilibrium remain elusive. Tet1 oxidase has been shown to play a key role in the active DNA demethylation in the CNS. In this...

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Pubblicato in:Neuroepigenetics
Autori principali: Kumar, Dinesh, Aggarwal, Milan, Kaas, Garrett A., Lewis, John, Wang, Jing, Ross, Daniel L., Zhong, Chun, Kennedy, Andrew, Song, Hongjun, Sweatt, J. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669576/
https://ncbi.nlm.nih.gov/pubmed/26644996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nepig.2015.10.002
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