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Stoichiometry and architecture of the human pyruvate dehydrogenase complex

The pyruvate dehydrogenase complex (PDHc) is a key megaenzyme linking glycolysis with the citric acid cycle. In mammalian PDHc, dihydrolipoamide acetyltransferase (E2) and the dihydrolipoamide dehydrogenase-binding protein (E3BP) form a 60-subunit core that associates with the peripheral subunits py...

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Publicado no:Sci Adv
Principais autores: Zdanowicz, Rafal, Afanasyev, Pavel, Pruška, Adam, Harrison, Julian A., Giese, Christoph, Boehringer, Daniel, Leitner, Alexander, Zenobi, Renato, Glockshuber, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2024
Assuntos:
Biomedicine and Life Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC466950/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/39018392/
https://ncbi.nlm.nih.govhttps://doi.org/10.1126/sciadv.adn4582
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