Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guérin (BCG) tuberculosis vaccine substrain Tokyo-172

BCG, only vaccine available to prevent tuberculosis, was established in the early 20th century by prolonged passaging of a virulent clinical strain of Mycobacterium bovis. BCG Tokyo-172, originally distributed within Japan in 1924, is one of the currently used reference substrains for the vaccine. R...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Wada, Takayuki, Maruyama, Fumito, Iwamoto, Tomotada, Maeda, Shinji, Yamamoto, Taro, Nakagawa, Ichiro, Yamamoto, Saburo, Ohara, Naoya
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669467/
https://ncbi.nlm.nih.gov/pubmed/26635118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17827
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