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Dimeric unnatural polyproline-rich peptides with enhanced antibacterial activity
We report a dimerization strategy to enhance the antibacterial potency of an otherwise weak cationic amphiphilic polyproline helical (CAPH) peptide. Overall, the dimeric CAPHs were more active against E. coli and S. aureus than the monomeric counterpart, reaching up to a 60-fold increase in potency....
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4669242/ https://ncbi.nlm.nih.gov/pubmed/24365160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.12.023 |
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