Randomized Controlled Trial of Zoledronic Acid plus Chemotherapy versus Chemotherapy Alone as Neoadjuvant Treatment of HER2-Negative Primary Breast Cancer (JONIE Study)

PURPOSE: Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption by inhibiting the mevalonate pathway. Its benefit for the prevention of skeletal complications due to bone metastases has been established. However, the antitumor eff...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hasegawa, Yoshie, Tanino, Hirokazu, Horiguchi, Jun, Miura, Daishu, Ishikawa, Takashi, Hayashi, Mitsuhiro, Takao, Shintaro, Kim, Seung Jin, Yamagami, Kazuhiko, Miyashita, Masaru, Konishi, Muneharu, Shigeoka, Yasushi, Suzuki, Masato, Taguchi, Tetsuya, Kubota, Tomoyuki, Akazawa, Kouhei, Kohno, Norio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669153/
https://ncbi.nlm.nih.gov/pubmed/26633806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143643
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