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Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents

Galactofuranose (Galf) is present in glycans critical for the virulence and viability of several pathogenic microbes, including Mycobacterium tuberculosis, yet the monosaccharide is absent from mammalian glycans. Uridine 5′-diphosphate-galactopyranose mutase (UGM) catalyzes the formation of UDP-Galf...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Kincaid, Virginia A., London, Nir, Wangkanont, Kittikhun, Wesener, Darryl A., Marcus, Sarah A., Héroux, Annie, Nedyalkova, Lyudmila, Talaat, Adel M., Forest, Katrina T., Shoichet, Brian K., Kiessling, Laura L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669066/
https://ncbi.nlm.nih.gov/pubmed/26214585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00370
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