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Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease

Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disorder characterised by accumulation of pathological isoforms of the prion protein, PrP. Although cases of clinical vCJD are rare, there is evidence there may be tens of thousands of infectious carriers in the United Kingdom alo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sawyer, Elizabeth B., Edgeworth, Julie Ann, Thomas, Claire, Collinge, John, Jackson, Graham S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668555/
https://ncbi.nlm.nih.gov/pubmed/26631638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17742
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