Fate of HIV-1 cDNA intermediates during reverse transcription is dictated by transcription initiation site of virus genomic RNA

Retroviral reverse transcription is accomplished by sequential strand-transfers of partial cDNA intermediates copied from viral genomic RNA. Here, we revealed an unprecedented role of 5′-end guanosine (G) of HIV-1 genomic RNA for reverse transcription. Based on current consensus for HIV-1 transcript...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Masuda, Takao, Sato, Yoko, Huang, Yu-Lun, Koi, Satoshi, Takahata, Tatsuro, Hasegawa, Atsuhiko, Kawai, Gota, Kannagi, Mari
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668388/
https://ncbi.nlm.nih.gov/pubmed/26631448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17680
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