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β-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection
Pneumolysin is one of the major virulence factors elaborated by Streptococcus pneumoniae; this toxin is a member of the cholesterol-dependent cytolysins. Engagement of cholesterol induces the formation of a multi-subunit complex by pneumolysin that lyses host cells by forming pores on the membrane....
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4668377/ https://ncbi.nlm.nih.gov/pubmed/26631364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17668 |
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