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Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson’s Disease

BACKGROUND: Preclinical and clinical studies have previously shown that systemic administration of GM1 ganglioside has neuroprotective and neurorestorative properties in Parkinson’s disease (PD) models and in PD patients. However, the clinical development of GM1 for PD has been hampered by its anima...

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Pubblicato in:PLoS One
Autori principali: Schneider, Jay S., Seyfried, Thomas N., Choi, Hyo-S., Kidd, Sarah K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668049/
https://ncbi.nlm.nih.gov/pubmed/26629687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143351
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