Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

Neisseria gonorrhoeae deploys a novel immune evasion strategy wherein the lacto-N-neotetraose (LNnT) structure of lipooligosaccharide (LOS) is capped by the bacterial sialyltransferase, using host cytidine-5’-monophosphate (CMP)-activated forms of the nine-carbon nonulosonate (NulO) sugar N-acetyl-n...

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發表在:PLoS Pathog
Main Authors: Gulati, Sunita, Schoenhofen, Ian C., Whitfield, Dennis M., Cox, Andrew D., Li, Jianjun, St. Michael, Frank, Vinogradov, Evgeny V., Stupak, Jacek, Zheng, Bo, Ohnishi, Makoto, Unemo, Magnus, Lewis, Lisa A., Taylor, Rachel E., Landig, Corinna S., Diaz, Sandra, Reed, George W., Varki, Ajit, Rice, Peter A., Ram, Sanjay
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668040/
https://ncbi.nlm.nih.gov/pubmed/26630657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005290
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