Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

Neisseria gonorrhoeae deploys a novel immune evasion strategy wherein the lacto-N-neotetraose (LNnT) structure of lipooligosaccharide (LOS) is capped by the bacterial sialyltransferase, using host cytidine-5’-monophosphate (CMP)-activated forms of the nine-carbon nonulosonate (NulO) sugar N-acetyl-n...

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Библиографические подробности
Опубликовано в: :PLoS Pathog
Главные авторы: Gulati, Sunita, Schoenhofen, Ian C., Whitfield, Dennis M., Cox, Andrew D., Li, Jianjun, St. Michael, Frank, Vinogradov, Evgeny V., Stupak, Jacek, Zheng, Bo, Ohnishi, Makoto, Unemo, Magnus, Lewis, Lisa A., Taylor, Rachel E., Landig, Corinna S., Diaz, Sandra, Reed, George W., Varki, Ajit, Rice, Peter A., Ram, Sanjay
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668040/
https://ncbi.nlm.nih.gov/pubmed/26630657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005290
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