Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

Neisseria gonorrhoeae deploys a novel immune evasion strategy wherein the lacto-N-neotetraose (LNnT) structure of lipooligosaccharide (LOS) is capped by the bacterial sialyltransferase, using host cytidine-5’-monophosphate (CMP)-activated forms of the nine-carbon nonulosonate (NulO) sugar N-acetyl-n...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Pathog
Egile Nagusiak: Gulati, Sunita, Schoenhofen, Ian C., Whitfield, Dennis M., Cox, Andrew D., Li, Jianjun, St. Michael, Frank, Vinogradov, Evgeny V., Stupak, Jacek, Zheng, Bo, Ohnishi, Makoto, Unemo, Magnus, Lewis, Lisa A., Taylor, Rachel E., Landig, Corinna S., Diaz, Sandra, Reed, George W., Varki, Ajit, Rice, Peter A., Ram, Sanjay
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668040/
https://ncbi.nlm.nih.gov/pubmed/26630657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005290
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