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The telomerase inhibitor imetelstat alone, and in combination with trastuzumab, decreases the cancer stem cell population and self-renewal of HER2(+) breast cancer cells
PURPOSE: Cancer stem cells (CSCs) are thought to be responsible for tumor progression, metastasis, and recurrence. HER2 overexpression is associated with increased CSCs, which may explain the aggressive phenotype and increased likelihood of recurrence for HER2(+) breast cancers. Telomerase is reacti...
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| Publicado no: | Breast Cancer Res Treat |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4667948/ https://ncbi.nlm.nih.gov/pubmed/25627551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3270-1 |
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