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Discovery of Natural Product-derived 5-HT1A Receptor Binders by Cheminfomatics Modeling of Known Binders, High Throughput Screening and Experimental Validation
The human 5-hydroxytryptamine receptor subtype 1A (5-HT1A) is highly expressed in the raphe nuclei region and limbic structures; for that reason 5-HT1A had served as a promising target for treating human mood disorders and neurodegenerative diseases. We have developed binary quantitative structure-a...
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| Veröffentlicht in: | Comb Chem High Throughput Screen |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4667780/ https://ncbi.nlm.nih.gov/pubmed/26138565 |
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