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Role of TrkB Kinase Activity in Aging Diaphragm Neuromuscular Junctions

Brain derived neurotrophic factor (BDNF) acting through the tropomyosin-related kinase receptor B (TrkB) enhances neuromuscular transmission in the diaphragm muscle of adult mice, reflecting presynaptic effects. With aging, BDNF enhancement of neuromuscular transmission is lost. We hypothesize that...

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Detalhes bibliográficos
Publicado no:Exp Gerontol
Main Authors: Greising, Sarah M., Stowe, Jessica M., Sieck, Gary C., Mantilla, Carlos B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667365/
https://ncbi.nlm.nih.gov/pubmed/26517952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2015.10.013
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