Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models

In order to further illuminate the potential role of dominant genetic variation in the “missing heritability” debate, we investigated the additive (narrow-sense heritability, h(2)) and dominant (δ(2)) genetic variance for 18 human complex traits. Within the same study base (10,682 Swedish twins), we...

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Vydáno v:Am J Hum Genet
Hlavní autoři: Chen, Xu, Kuja-Halkola, Ralf, Rahman, Iffat, Arpegård, Johannes, Viktorin, Alexander, Karlsson, Robert, Hägg, Sara, Svensson, Per, Pedersen, Nancy L., Magnusson, Patrik K.E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667127/
https://ncbi.nlm.nih.gov/pubmed/26544805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.10.004
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