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Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,363 immunocompetent adults. Significant associ...

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Podrobná bibliografie
Vydáno v:Am J Hum Genet
Hlavní autoři: Hammer, Christian, Begemann, Martin, McLaren, Paul J., Bartha, István, Michel, Angelika, Klose, Beate, Schmitt, Corinna, Waterboer, Tim, Pawlita, Michael, Schulz, Thomas F., Ehrenreich, Hannelore, Fellay, Jacques
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667104/
https://ncbi.nlm.nih.gov/pubmed/26456283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.09.008
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