Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity

Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto’s disease—the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is directed mainly at two surface regions on the molecul...

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Veröffentlicht in:PLoS One
Hauptverfasser: Le, Sarah N., Porebski, Benjamin T., McCoey, Julia, Fodor, James, Riley, Blake, Godlewska, Marlena, Góra, Monika, Czarnocka, Barbara, Banga, J Paul, Hoke, David E., Kass, Itamar, Buckle, Ashley M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666655/
https://ncbi.nlm.nih.gov/pubmed/26623656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142615
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