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Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

Sirtuins constitute a family of NAD(+)-dependent enzymes that catalyse the cleavage of various acyl groups from the ∊-amino group of lysines. They regulate a series of cellular processes and their misregulation has been implicated in various diseases, making sirtuins attractive drug targets. To date...

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Veröffentlicht in:Acta Crystallogr F Struct Biol Commun
Hauptverfasser: Rumpf, Tobias, Gerhardt, Stefan, Einsle, Oliver, Jung, Manfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666478/
https://ncbi.nlm.nih.gov/pubmed/26625292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15019986
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