Safety, pharmacokinetics and efficacy findings in an open-label, single-arm study of weekly paclitaxel plus lapatinib as first-line therapy for Japanese women with HER2-positive metastatic breast cancer

BACKGROUND: Lapatinib is the human epidermal growth factor receptor 2 (HER2) targeting agent approved globally for HER2-positive metastatic breast cancer (MBC). The efficacy, safety and pharmacokinetics (PK) of lapatinib combined with paclitaxel (L+P) were investigated in this study, to establish cl...

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Detalles Bibliográficos
Publicado en:Int J Clin Oncol
Autores principales: Inoue, Kenichi, Kuroi, Katsumasa, Shimizu, Satoru, Rai, Yoshiaki, Aogi, Kenjiro, Masuda, Norikazu, Nakayama, Takahiro, Iwata, Hiroji, Nishimura, Yuichiro, Armour, Alison, Sasaki, Yasutsuna
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Japan 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666271/
https://ncbi.nlm.nih.gov/pubmed/25967286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10147-015-0832-5
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