Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation

Breast cancer encompasses a heterogeneous group of diseases at the molecular level. It is known that chemo-sensitivity of breast cancer depends on its molecular subtype. We investigated the growth inhibitory effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, and the mechanism of...

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Publicado en:Int J Oncol
Autores principales: MAWATARI, TOSHIKI, NINOMIYA, ITASU, INOKUCHI, MASAFUMI, HARADA, SHINICHI, HAYASHI, HIRONORI, OYAMA, KATSUNOBU, MAKINO, ISAMU, NAKAGAWARA, HISATOSHI, MIYASHITA, TOMOHARU, TAJIMA, HIDEHIRO, TAKAMURA, HIROYUKI, FUSHIDA, SACHIO, OHTA, TETSUO
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2015
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665753/
https://ncbi.nlm.nih.gov/pubmed/26497673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2015.3213
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