Knockdown of heme oxygenase-1 promotes apoptosis and autophagy and enhances the cytotoxicity of doxorubicin in breast cancer cells

Heme oxygenase-1 (HMOX-1) is a microsomal enzyme that exerts anti-apoptotic and cytoprotective effects. In the present study, HMOX-1 was demonstrated to be overexpressed and able to be induced by doxorubicin in breast cancer cell lines. Knockdown of HMOX-1 using short interfering (si)RNA enhanced th...

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Udgivet i:Oncol Lett
Main Authors: ZHU, XIAO-FENG, LI, WEN, MA, JIE-YI, SHAO, NAN, ZHANG, YUN-JIAN, LIU, RUI-MING, WU, WEI-BIN, LIN, YING, WANG, SHEN-MING
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665608/
https://ncbi.nlm.nih.gov/pubmed/26722274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2015.3735
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