Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma

In this study, we developed a novel poly (lactic-co-glycolic acid)-dextran (PLD)-based nanodelivery system to enhance the anticancer potential of cisplatin (CDDP) in osteosarcoma cells. A nanosized CDDP-loaded PLGA-DX nanoparticle (PLD/CDDP) controlled the release rate of CDDP up to 48 h. In vitro c...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Liu, Ping, Sun, Liang, Zhou, Dong-sheng, Zhang, Peng, Wang, Yong-hui, Li, Dong, Li, Qing-hu, Feng, Rong-jie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664968/
https://ncbi.nlm.nih.gov/pubmed/26619950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17387
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