Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

Citrate is a key regulatory metabolic intermediate as it facilitates the integration of the glycolysis and lipid synthesis pathways. Inhibition of hepatic extracellular citrate uptake, by blocking the sodium-coupled citrate transporter (NaCT or SLC13A5), has been suggested as a potential therapeutic...

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הוצא לאור ב:Sci Rep
Main Authors: Huard, Kim, Brown, Janice, Jones, Jessica C., Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B., Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E., Magee, Thomas V., Uccello, Daniel P., Loria, Paula, Di, Li, Gosset, James R., Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A., Erion, Derek M.
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2015
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664966/
https://ncbi.nlm.nih.gov/pubmed/26620127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17391
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