Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(−/−) mouse model

Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that can develop into liver cirrhosis and cancer. Elongation of very long chain fatty acids (ELOVL) family member 6 (Elovl6) is a microsomal enzyme that regulates the elongation of C12–16 saturated...

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Publicado no:Sci Rep
Main Authors: Kuba, Motoko, Matsuzaka, Takashi, Matsumori, Rie, Saito, Ryo, Kaga, Naoko, Taka, Hikari, Ikehata, Kei, Okada, Naduki, Kikuchi, Takuya, Ohno, Hiroshi, Han, Song-iee, Takeuchi, Yoshinori, Kobayashi, Kazuto, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Yahagi, Naoya, Arakawa, Yoji, Fujimura, Tsutomu, Nakagawa, Yoshimi, Yamada, Nobuhiro, Shimano, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664962/
https://ncbi.nlm.nih.gov/pubmed/26619823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17604
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