Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.

Recent interest in therapies for sickle cell anemia based on elevating fetal Hb has made accurate estimates of the sparing effect of fetal Hb (Hb F) and other non-sickle Hbs on sickle Hb (Hb S) polymerization essential. We have developed a technique, using HbCO as surrogate for HbO2, that enables us...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Poillon, W N, Kim, B C, Rodgers, G P, Noguchi, C T, Schechter, A N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7685112/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5039
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