Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope

The sigma-1 receptor (Sig-1R) chaperone at the endoplasmic reticulum (ER) plays important roles in cellular regulation. Here we found a new function of Sig-1R, in that it translocates from the ER to the nuclear envelope (NE) to recruit chromatin-remodeling molecules and regulate the gene transcripti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tsai, Shang-Yi A., Chuang, Jian-Ying, Tsai, Meng-Shan, Wang, Xiao-fei, Xi, Zheng-Xiong, Hung, Jan-Jong, Chang, Wen-Chang, Bonci, Antonello, Su, Tsung-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664336/
https://ncbi.nlm.nih.gov/pubmed/26554014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518894112
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