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Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells

Tumor-initiating cells, also designated as cancer stem cells, are proposed to constitute a subpopulation of malignant cells central to tumorigenesis, metastasis, and treatment resistance. We analyzed activity of the proteasome, the primary organelle for targeted protein degradation, as a marker of t...

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Bibliografske podrobnosti
izdano v:Mol Imaging
Main Authors: Stacer, Amanda C., Wang, Hanxiao, Fenner, Joseph, Dosch, Joseph S., Salomonnson, Anna, Luker, Kathryn E., Luker, Gary D., Rehemtulla, Alnawaz, Ross, Brian D.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663702/
https://ncbi.nlm.nih.gov/pubmed/26431589
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