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Inhibition of insulin fibrillation by osmolytes: Mechanistic Insights

We have studied here using a number of biophysical tools the effects of osmolytes, betaine, citrulline, proline and sorbitol which differ significantly in terms of their physical characteristics such as, charge distribution, polarity, H-bonding abilities etc, on the fibrillation of insulin. Among th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Choudhary, Sinjan, Kishore, Nand, Hosur, Ramakrishna V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663473/
https://ncbi.nlm.nih.gov/pubmed/26616401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17599
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