AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression

Here we studied the impact of 5-aminoimidazole-4-carboxamide riboside (AICAR), a well-known AMPK activator, on cardiac metabolic adaptation. AMPK activation by AICAR was confirmed by increased phospho-Thr(172)-AMPK and phospho-Ser(79)-ACC protein levels in HL-1 cardiomyocytes. Then, cells were expos...

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Bibliographische Detailangaben
Veröffentlicht in:PPAR Res
Hauptverfasser: Rodríguez-Calvo, Ricardo, Vázquez-Carrera, Manuel, Masana, Luis, Neumann, Dietbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663352/
https://ncbi.nlm.nih.gov/pubmed/26649034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/785783
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