The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism

Manipulation of metabolic pathways in hematological cancers has therapeutic potential. Here, we determined the molecular mechanism of action of the metabolic modulator dichloroacetate (DCA) in leukemic cells. We found that DCA induces the AMP-activated protein kinase (AMPK)/p53 pathway with increase...

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Gardado en:
Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Allende-Vega, Nerea, Krzywinska, Ewelina, Orecchioni, Stefania, Lopez-Royuela, Nuria, Reggiani, Francesca, Talarico, Giovanna, Rossi, Jean-François, Rossignol, Rodrigue, Hicheri, Yosr, Cartron, Guillaume, Bertolini, Francesco, Villalba, Martin
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662487/
https://ncbi.nlm.nih.gov/pubmed/26231043
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