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Mechanisms in dominant parkinsonism; The toxic triangle of LRRK2, α-synuclein and tau
Parkinson’s disease (PD) is generally sporadic but a number of genetic diseases have parkinsonism as a clinical feature. Two dominant genes, α-synuclein and leucine rich repeat kinase 2 (LRRK2), are important for understanding inherited and sporadic PD. α-Synuclein is a major component of pathologic...
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| Udgivet i: | Bioessays |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4662284/ https://ncbi.nlm.nih.gov/pubmed/20127702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.200900163 |
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