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Mechanisms in dominant parkinsonism; The toxic triangle of LRRK2, α-synuclein and tau

Parkinson’s disease (PD) is generally sporadic but a number of genetic diseases have parkinsonism as a clinical feature. Two dominant genes, α-synuclein and leucine rich repeat kinase 2 (LRRK2), are important for understanding inherited and sporadic PD. α-Synuclein is a major component of pathologic...

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Bibliografiske detaljer
Udgivet i:Bioessays
Main Authors: Taymans, Jean-Marc, Cookson, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662284/
https://ncbi.nlm.nih.gov/pubmed/20127702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.200900163
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