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Alteration of the Donor/Acceptor Spectrum of the (S)-Amine Transaminase from Vibrio fluvialis

To alter the amine donor/acceptor spectrum of an (S)-selective amine transaminase (ATA), a library based on the Vibrio fluvialis ATA targeting four residues close to the active site (L56, W57, R415 and L417) was created. A 3DM-derived alignment comprising fold class I pyridoxal-5′-phosphate (PLP)-de...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Genz, Maika, Vickers, Clare, van den Bergh, Tom, Joosten, Henk-Jan, Dörr, Mark, Höhne, Matthias, Bornscheuer, Uwe T.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661865/
https://ncbi.nlm.nih.gov/pubmed/26569229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms161126007
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