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Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein.

Ras p120 GTPase activation protein (GAP), a cytosolic protein, is a negative mediator and potential downstream effector of Ras function. Since membrane association is critical for Ras function, we introduced the Ras membrane-targeting signal (a 19-residue peptide ending in CAAX, where C = cysteine,...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Clark, G J, Quilliam, L A, Hisaka, M M, Der, C J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46618/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8506332/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.4887
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