Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase

Phospholemman (FXYD1) is a single-transmembrane protein regulator of Na,K-ATPase, expressed strongly in heart, skeletal muscle, and brain and phosphorylated by protein kinases A and C at Ser-68 and Ser-63, respectively. Binding of FXYD1 reduces Na,K-ATPase activity, and phosphorylation at Ser-68 or...

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Vydáno v:J Biol Chem
Hlavní autoři: Mishra, Neeraj Kumar, Habeck, Michael, Kirchner, Corinna, Haviv, Haim, Peleg, Yoav, Eisenstein, Miriam, Apell, Hans Juergen, Karlish, Steven J. D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661392/
https://ncbi.nlm.nih.gov/pubmed/26429909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687913
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