Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes

α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free c...

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Bibliographic Details
Published in:Beilstein J Org Chem
Main Authors: Zemtsov, Artem A, Volodin, Alexander D, Levin, Vitalij V, Struchkova, Marina I, Dilman, Alexander D
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2015
Subjects:
Letter
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660974/
https://ncbi.nlm.nih.gov/pubmed/26664635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.11.231
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