Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

BACKGROUND: Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain. METHODS: We used lipopolysaccharide (LPS) to induce...

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Pubblicato in:J Neuroinflammation
Autori principali: Banks, William A., Gray, Alicia M., Erickson, Michelle A., Salameh, Therese S., Damodarasamy, Mamatha, Sheibani, Nader, Meabon, James S., Wing, Emily E., Morofuji, Yoichi, Cook, David G., Reed, May J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660627/
https://ncbi.nlm.nih.gov/pubmed/26608623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0434-1
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