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Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice
Sperm–egg fusion is indispensable for completing mammalian fertilization. Although the underlying molecular mechanisms are poorly understood, requirement of two spermatozoon factors, IZUMO1 and SPACA6, and two oocyte factors, CD9 and the IZUMO1 counter-receptor JUNO, has been proven by gene disrupti...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Pub. Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4660202/ https://ncbi.nlm.nih.gov/pubmed/26568141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9858 |
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