Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models

BACKGROUND: Trisomy 21 causes Down syndrome (DS), but the mechanisms by which the extra chromosome leads to deficient intellectual and immune function are not well understood. RESULTS: Here, we profile CpG methylation in DS and control cerebral and cerebellar cortex of adults and cerebrum of fetuses...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Mendioroz, Maite, Do, Catherine, Jiang, Xiaoling, Liu, Chunhong, Darbary, Huferesh K., Lang, Charles F., Lin, John, Thomas, Anna, Abu-Amero, Sayeda, Stanier, Philip, Temkin, Alexis, Yale, Alexander, Liu, Meng-Min, Li, Yang, Salas, Martha, Kerkel, Kristi, Capone, George, Silverman, Wayne, Yu, Y. Eugene, Moore, Gudrun, Wegiel, Jerzy, Tycko, Benjamin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659173/
https://ncbi.nlm.nih.gov/pubmed/26607552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0827-6
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